Blood groups are classified into systems based on specific antigens present on red blood cells. As the ABO and Rh systems are the most recognise, there are 47 blood group systems in total, encompassing over 360 antigens.
New research led by NHS Blood and Transplant scientists has unveil a new blood group system call as MAL, which includes the AnWj antigen.
Although this antigen was first identified in 1972, its genetic foundation has only recently been understood.
Dr. Louise Tilley from NHS Blood and Transplant spearhead the research on the MAL system, marking a significant breakthrough.
Dr. Louise Tilley Said :
“The genetic background of AnWj has been a mystery for over 50 years,”.
“Our team’s work to resolve this has been a major milestone, enabling us to offer improved care for patients with rare blood types.”
This identification of the MAL system is crucial for patients who are AnWj-negative.
These individuals can suffer severe reactions if given AnWj-positive blood.
This new discovery allows for the creation of genotyping tests to identify these rare cases, thereby reducing transfusion-related risks.
Over 99.9% of people are AnWj-positive, with the Mal protein present on their red blood cells.
Those who lack this protein may do so due to genetic reasons or specific health conditions.
The research team, including Professor Ash Toye from the University of Bristol and Dr. Nicole Thornton from NHS Blood and Transplant, use whole exome sequencing to identify deletions in the MAL gene associate with the AnWj-negative phenotype.
Ash Toye Said :
“It’s exciting to confirm AnWj’s genetic basis using advanced gene manipulation techniques,”.
Dr. Tim Satchwell from UWE Bristol highlight the difficulty in identifying the MAL protein due to its small size and unique properties.
This discovery is expect to improve blood transfusion safety and facilitate the identification of rare donors and patients, enhancing overall care.
