Scientists have developed a compound that can kill some hard-to-treat cancer types. This findings are part of a new study publish recently in the Nature Science.
The new compound targets the vulnerability that wasn’t explore by researchers before.
As per the study leader and professor of obstetrics and gynecology at UT Health Centre at San Antonio, Ratna Vadlamudi, PhD, the scientists identified a critical vulnerability in multiple cancers and validated the findings in multiple cancer cell types and animal models.
The professor add that the compound was found to have work on a range of cell lines and xenografts, which shows it is “targeting a fundamental vulnerability in cancer cells.”
Vadlamudi and his colleagues had discover a compound called ERX-11 while working at the Ratna Vadlamudi Lab, University of Texas Health Centre at San Antonio in 2017.
The lab is gear up towards developing small-molecule inhibitors for therapy-resistant cancers by studying ovarian and breast cancers.
The ERX-11 compound targets the estrogen receptor (ER), which is the leading cause behind most of the breast cancers.
After the compound was identified, scientists scan through a screen of chemical analogs of ERX-11 and observe that another compound name ERX-41 was effective in killing ER-positive cancers in petri dishes.
It was also found that the compound manage to eliminate triple-negative breast cancers (TNBCs).
The finding was significant as there is a lack of targeted treatments for TNBC due to the absence of progesterone, estrogen, and human epidermal growth factor 2 in it.
Casting the net wider, scientists, using mouse models, highlight that ERX-41 also show activity against a large number of human tumours.
It was learn that the compound effectively shrunk the tumours in mouse models without resulting in toxicity in the animals or affecting normal breast cells.
ERX-41 prove to be working against other cancer types with elevated endoplasmic reticulum stress.
These include cancers that don’t have many effective treatments for them like ovarian cancers, glioblastoma, and pancreatic cancers.
Scientists hope that this findings would help in development of new drugs bolstering the fight against some cancers.
